Nano suspension ultra high speed colloid mill

Nano suspension homogenizer, suspension homogenizer, ultra high speed homogenizer,ApiSuspension homogenizer, paclitaxel nano suspension homogenizer, ketoprofen nano suspension homogenizer, itraconazole nano suspension gel homogenizer, celecoxib nano suspension homogenizer, budesonide inhalation suspension homogenizer areHomogenization is the process of mixing different substances to obtain a homogeneous mixture. Homogenization is mainly applied to components that are immiscible and almost or completely immiscible.

Nano suspension homogenizer, suspension homogenizer, ultra high speed homogenizer,Api suspension homogenizer, paclitaxel nanosuspension homogenizer

Characteristics of nano suspension:

Nano suspension is a colloidal dispersion system of "pure" nano drug particles. Unlike traditional matrix skeleton nano systems, nano suspension does not require a carrier material. It disperses nano scale drug particles in water through the stabilizing effect of surfactants to form a stable dispersion system.

Due to the characteristics of nanosuspensions, they exhibit unique advantages in various routes of administration, such as simple prescription, rapid preparation, reduced screening costs for active compounds, improved drug and bioavailability, elimination of irritants and toxic side effects caused by additional ingredients, and lower administration volume.

Preparation of nanosuspension:

The preparation of nanosuspensions mainly involves two aspects, namely prescription screening and process optimization. Prescription screening mainly involves selecting the type and dosage of surfactants to improve the long-term stability of the product. Process optimization is achieved by adjusting production processes and parameters such as pressure and cycle times of high-pressure homogenizers to obtain ideal particle size distribution

The preparation methods of nanosuspensions mainly include grinding method, ultrasonic method, and homogenization method. The first two preparation methods both have grinding media or metal residues, while the homogenization method has low metal residue and is easy for industrial production

Homogenization method:

The direct homogenization method utilizes the cavitation and air hole effects caused by the ultra high speed homogenizer to further pulverize the micronized drug particles into nanoscale particles, while reducing the polydispersity of the drug particle size. The direct homogenization method can avoid the addition of organic solvents and is suitable for drugs that are difficult to dissolve in both water and oil, with good reproducibility of the process. The particle size of the product is determined by the hardness of the drug itself, homogeneous shear, and the number of cycles. By adjusting the speed and number of cycles of the ultra high speed homogenizer, a suitable particle size distribution can be obtained.

Application case:

Api suspension, paclitaxel nano suspension, ketoprofen nano suspension, itraconazole nano suspension gel

Celecoxib nanosuspension, Budesonide inhalation suspension

Equipment features:

Complementary feeding and stable pressure overlap; Double plunger high-pressure implementation, high precision of the feed liquid, and narrow distribution of PID peak values; High pressure double crushing, stable suspension, and the ability to achieve long-term non stratification.

Grinding and dispersing machine is a high-tech product composed of colloid grinding and dispersing machines.

The first level consists of three-level sawtooth protrusions and grooves with increasing precision. The stator can be infinitely adjusted to the desired distance between the rotors. Under enhanced fluid turbulence. The groove can change direction at each level.
The second stage is composed of a stator. The design of the dispersing head also effectively meets the needs of substances with different viscosities and particle sizes. The difference in the design of the stator and rotor (emulsifying head) between online and batch machines is mainly due to the requirements for conveying performance. It is particularly important to note that the difference between coarse precision, medium precision, fine precision, and other types of working heads is not only the arrangement of specified rotor teeth, but also an important difference in the geometric characteristics of different working heads. The width of the slot and other geometric features can alter the different functions of the stator and rotor working heads.

The following is a model table for reference:

Nano suspension ultra high speed colloid mill